Depression strikes at some point in everyone life. It is related to common cold ofmental disorder that affects every individual. Depression not only effects person mentally but also physically and also affects their thoughts. Everyone feel sad, but this sad feeling is usually for short-lived and passes out within few days. But when depression occurs, it interferes with daily routine and lead to cause pain. It is a common but serious health issue. Women are at more risk than male. About 15 millions of people are affected by depression and almost 15% commit suicide. It is more common disorder than Diabetes, Cancer and AIDs. Antidepressants are relief for those patients who are suffering from depression. They help to balance important chemicals called neurotransmitters in the body and improve energy level and mood in individual. Drugs are available to treat depression. Medications like Celebrex, Pristiq, Prozac, Remeron, Seroquel, Zoloft tablets, Symbyax, Tofranil, Stablon, Sibelium, Prednisolone, Paxil, Luvox, Maxalt, Adapin, Anafranil, Aventyl, Celexa, Cymbalta, Desyrel, Elavil and Lexapro helps to treat the symptoms depression. Avoid smoking and alcohol. Daily exercise can help to keep depression under control.